Wikipedia has this to say about the serum run:
During the 1925 serum run to Nome, also known as the "Great Race of Mercy", 20 mushers and about 150 sled dogs relayed diphtheria antitoxin 674 miles (1,085 km) by dog sled across the U.S. territory of Alaska in five and a half days, saving the small city of Nome and the surrounding communities from an incipient epidemic.The notion that the Iditarod recreates the serum run has been perpetuated by the media over the years. But, the Iditarod Race was really patterned after the All-Alaska Sweepstakes of 1907-8.
Both the mushers and their dogs were portrayed as heroes in the newly popular medium of radio, and received headline coverage in newspapers across the United States. Balto, the lead sled dog on the final stretch into Nome, became the most famous canine celebrity of the era after Rin Tin Tin, and his statue is a popular tourist attraction in New York City's Central Park. The publicity also helped spur an inoculation campaign in the U.S. that dramatically reduced the threat of the disease.
The sled dog was the primary means of transportation and communication in subarctic communities around the world, and the race became both the last great hurrah and the most famous event in the history of mushing, before first aircraft in the 1930s and then the snowmobile in the 1960s drove the dog sled almost intoextinction.
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